bv伟德源自英国始于1946-Venice Dream City

王琳琳，博士，bv伟德源自英国始于1946副研究员。主要从事食品微生物学、食品营养与健康等方面的研究工作。研究方向集中在肠道微生物与健康、功能性益生菌资源发掘、益生菌功能机制解析及益生菌产品开发。主攻益生菌对消化道疾病的影响及其相关机制的解析。主持“十四五”子课题1项，国家自然基金2项，江苏省自然科学基金，中博后，省博后科学基金等科研项目3项；参与自然基金国际项目及国家级项目各1项；获教育部高等学校科学技术进步奖二等奖等省部级奖励2项，申请国家发明专利16项，在国内外主流学术期刊上发表科技论文30余篇。参与《Lactic Acid Bacteria: Bioengineering and Industrial Applications》（Springer出版社）、《乳酸菌科学与技术》（科学出版社）的编写工作。

1.国家“十四五”重点研发计划项目子课题：特殊生命周期人群营养需求与代谢模式研究，2022.10-2026.10，主持

2.国家自然科学基金面上项目，32172213，基于短链脂肪酸生物合成解析两歧双歧杆菌CCFM16调节肠动力的机制，2022.01-2025.12，主持

3.国家自然科学青年基金，81800469，基于肠道微生态及黏膜免疫解析双歧杆菌黏附性差异及其对便秘的影响，2019.01-2021.12，主持

4.江苏省青年基金项目，江苏省科学技术厅，BK20180613，从肠道微生态及黏膜免疫角度解析黏附性双歧杆菌缓解便秘的机制，2018.07-2021.06，主持

5.中国博士后科学基金，2018M642164，2019.01-2020.12，主持

6.江苏省博士后科学基金，2018K090C，2018.06-2020.01，主持

7.江南大学基本科研计划青年基金，JUSRP121001，2021.01.01—2022.12.31，主持

1.Linlin Wang, Lujun Hu, Shuang Yan, Tian Jiang, Shuguang Fang, Gang Wang*, Jianxin Zhao, Hao Zhang, Wei Chen. Effects of different oligosaccharides at various dosages on the composition of gut microbiota and short-chain fatty acids in mice with constipation, Food & Function, 2017, 8:1966-1978.

2．Linlin Wang, Mingluo Pan, Dongyao Li, Yiting Yin, Tian Jiang, Shuguang Fang, Gang Wang*, Jianxin Zhao, Hao Zhang*, Wei Chen. Metagenomic insights into the effects of oligosaccharides on the microbial composition of cecal contents in constipated mice. Journal of Functional Foods, 2017, 38:486-496.

3.Linlin Wang, Lujun Hu, Qi Xu, Boxing Yin, Dongsheng Fang, Gang Wang*, Jianxin Zhao, Hao Zhang and Wei Chen. Bifidobacterium adolescentis Exerts Strain-Specific Effects on Constipation Induced by Loperamide in BALB/c Mice, Int J Mol Sci, 2017, 18(2):318-339.

4.Linlin Wang, Lujun Hu, Qi Xu, Tian Jiang, Shuguang Fang, Gang Wang*, Jianxin Zhao, Hao Zhang* and Wei Chen. Bifidobacteria exerts species-specific effects on constipation in BALB/c mice, Food & Function, 2017. 8(10):3587-3600.

5.Linlin Wang, Cailing Chen, Shumao Cui, Yuan-kun Lee, Gang Wang*, Jianxin Zhao, Hao Zhang and Wei Chen. Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice. Front Microbiol. 2019, 10: 1721-1736.

6.Linlin Wang, Shi Cen, Gang Wang*, Yuan-kun Lee, Jianxin Zhao, Hao Zhang, Wei Chen. Acetic acid and butyric acid released in large intestine play different roles in the alleviation of constipation. Journal of Functional Foods, 2020, 69:103953-103962.

7.Linlin Wang, Mao Chai, Jialiang Wang, Qiangqing YU, Gang Wang, Hao Zhang, Jianxin Zhao*and Wei Chen. Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice. Food Funct., 2022,13, 5037-5049.

8.Linlin Wang, Ting Jiao, Qiangqing Yu, Jialiang Wang, Luyao Wang, Gang Wang, Hao Zhang, Jianxin Zhao* and Wei Chen. Bifidobacterium bifidum Shows More Diversified Ways of Relieving Non-Alcoholic Fatty Liver Compared with Bifidobacterium adolescentis. Biomedicines, 2022,10,84 -100.

9. Mao Chai†,Linlin Wang†, Xinping Li, Jianxin Zhao, Hao Zhang, Gang Wang* and Wei Chen. Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation. Food Funct., 2021,12,6058–6069.

10. Luyao Wang‡,Linlin Wang‡, Peijun Tian, Botao Wang, Shumao Cui, JianxinZhao, Hao Zhang, Long Qian, Qun Wang, Wei Chen and Gang Wang*. A randomised, double-blind, placebo-controlled trial of Bifidobacterium bifidum CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct., 2022,13,1628 -1640.

1.教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖，2018，排名第十一

2．中国商业联合会科学技术奖二等奖，2018，排名第十

1.陈卫，王刚，王琳琳，赵建新，张灏.一种两歧双歧杆菌及其用途.中国，专利号：CN201710128300.1.

2.王琳琳,王刚,李鑫萍,赵建新,陈卫,张灏.一株缓解泻剂结肠的副干酪乳杆菌及其应用.

中国，专利号：2021103398241.

3.王琳琳,王刚,柴茂,赵建新,陈卫,张灏.一株缓解便秘并调节肠道菌群紊乱的两歧

双歧杆菌及其应用.中国，专利号：CN 2021103131194.

4.王刚,王琳琳，柴茂，赵建新，陈卫，张灏.缓解便秘的两歧双歧杆菌及其制备的发酵

食品与益生菌制剂.中国发明专利申请，专利申请号：CN 202110313301X.

5.王刚，柴茂，王琳琳，赵建新，陈卫，张灏.一株减少结肠病理损伤且具有缓解便秘

作用的两歧双歧杆菌.中国，专利号：CN 2021103124449.

6.王刚,李鑫萍,王琳琳,赵建新,陈卫,张灏.一株缓解泻剂结肠的两歧双歧杆菌及其应用.中国，专利号：CN 2021103414723.

7.王刚，朱慧越，王琳琳等.一种利用酰化淀粉定点释放短链脂肪酸的抗抑郁的方法.中国，专利号：CN 2020107582456.